Daptomycin for Methicillin-Resistant Staphylococcus aureus Bloodstream Infection and Elevated Vancomycin Minimum Inhibitory Concentrations: Has the Time Come?

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Daptomycin for methicillin-resistant Staphylococcus aureus bloodstream infection and elevated vancomycin minimum inhibitory concentrations: has the time come?

In this issue, Moore et al [1] provide the first data investigating the results of using an alternative agent in patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) with elevated vancomycin minimum inhibitory concentrations (MICs). In this retrospective analysis, funded by an InvestigatorInitiated Research Grant from Cubist Pharmaceuticals, investigators...

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Vancomycin Creep and Daptomycin Minimum Inhibitory Concentra- tion in Methicillin-Resistant Staphylococcus aureus

Objective: To determine the in vitro activity of daptomycin and vancomycin against 50 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from blood and pus specimens. Material and methods: Fifty consecutive MRSA were isolated from pus (n=25) and blood (n=25) were included in the study. Oxacillin susceptibility was determined by cefoxitin disc diffusion, green colored colonie...

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Optimizing the detection of methicillin-resistant Staphylococcus aureus with elevated vancomycin minimum inhibitory concentrations within the susceptible range

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Daptomycin or vancomycin for methicillin-resistant Staphylococcus aureus with a vancomycin minimum inhibitory concentration >1 μg/L.

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2011

ISSN: 1537-6591,1058-4838

DOI: 10.1093/cid/cir777